Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. Learn to concoct simple home remedies with easy-to-grow medicinal herbs, Some are looking to alternative medicines to help prevent or treat diseases like cancer. . Beware that milk thistle can worsen depression, it doesn't act the same on everybody. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Malaria. About curcumin, it isn't usually a problem but if you're on IMAOs you may like to read a bit before taking high doses. Milk Thistle & Silymarin Benefits & Uses (incl. Liver Detox) Tadaah, perhaps a partly explanation for your experience? Generic name: milk thistle [MILK-THIH-sull] However, many of these potential benefits are not backed by science. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. People sometimes eat the stem and leaves of milk thistle in salads. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Reflux Risk and Relief View More . When considering the use of herbal supplements, seek the advice of your doctor. Milk thistle is generally considered safe when taken by mouth (1, 45). Milk thistle ( Silybum marianum) is an herbal remedy used mainly to protect and detoxify the liver. Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. Advanced milk thistle extract contains phytonutrients that fight oxidative stress and support liver health. Milk Thistle: Benefits and Side Effects - WebMD This is especially important if you are taking any other medications for menopause or any blood thinners, such as statins. All rights reserved. Tajmohammadi A, Razavi BM, Hosseinzadeh H. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. https://www.nccih.nih.gov/health/milk-thistle. Its been suggested that oxidative stress in the body may play a role in the development of acne (41). Website: https://pubmed.ncbi.nlm.nih.gov/. The site is secure. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. In: Drugs and Lactation Database (LactMed). Now, one substance that we know can inhibit 5-alpha reductase, although it does it pretty weakly, is saw palmetto [200-500mg/Day, 2-3 . Epub 2016 Dec 22. There is no standardized dosage or recommended intake for milk thistle tea, but it's generally considered safe if consumed in moderation. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: an allergy to plants such as ragweed, chrysanthemums, marigolds, or daisies. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Song X, Zhou B, Zhang P, Lei D, Wang Y, Yao G, Hayashi T, Xia M, Tashiro S, Onodera S, Ikejima T. Neurochem Res. Historically, people have used milk thistle for liver disorders and gallbladder problems. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Therefore, it may be best to avoid milk thistle during these life stages. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. Acne is a chronic inflammatory skin condition. Milk Thistle Tea: Benefits, Side Effects, and Dosage. JAMA. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Milk thistle is a plant also known as Artichaut Sauvage, Cardo Lechoso, Cardui Mariae, Carduus marianus, Chardon Argent, Chardon de Marie, pine Blanche, Holy Thistle, Lady's Thistle, Lait de Notre-Dame, Legalon, Marian Thistle, Mariendistel, Mary Thistle, Shui Fei Ji, Silibinin, Silybe de Marie, Silybum, Silymarin, and other names. 2018;8:65-74. doi:10.2147/PTT.S169333. 2016;68(4):1026-1073. doi:10.1124/pr.115.010843. Clipboard, Search History, and several other advanced features are temporarily unavailable. Just amazing and timely information at your fingertips. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. It is possibly effective in diabetes and indigestion (). Researchers also have found that milk thistle improved insulin resistance, a key part of type 2 diabetes. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. 10 Supplements You Should Be Taking After Menopause Summary Milk thistle may increase breast milk production in women who are lactating, though very little research has been done to confirm its effects. J Med Assoc Thai. Before Its unclear what benefits, if any, it may have in the body, but its sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. Theres conflicting research on the benefits of milk thistle for liver health. Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. https://www.micromedexsolutions.com. The benefits of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Trigonella foenum-graecum(fenugreek)also is used for this reason. Milk thistle has been shown in experimental test-tube and animal studies to stimulate bone mineralization and potentially be protective against bone loss (22, 23). Medically reviewed by Drugs.com on Sep 29, 2022. Milk thistle is often sold as an herbal supplement. Eighteen clinical trials of 1,088 participants were assessed. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Silibinin is one of the main flavonoids produced by milk thistle, which is reported to inhibit the inflammatory response by suppressing the nuclear factor-kappa B (NF-B) pathway. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. 2014;2014:941085. doi:10.1155/2014/941085. Here are 10 of the best herbs for your liver, including benefits and. Its not known whether milk thistle is helpful for other conditions. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Botanicals and their bioactive phytochemicals for women's health, Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review, Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. Have direct benefits against prostate, breast, and certain cervical cancer cells. Side effects. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Milk Thistle Can Help Fight Symptoms of OCD - Natural Wellness Update However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations (44). Epub 2019 Nov 24. Milk thistle can trigger allergic reactions. Unexpected effects from milk thistle. Do not use this product without medical advice if you are breast-feeding a baby. Song X, Zhou B, Cui L, Lei D, Zhang P, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Onodera S, Ikejima T. Neurochem Res. Learn. Milk thistle has a distinctive purple flower and spiky leaves, grows to about 200 cm in height, and is found throughout the world. 7 likes, 2 comments - lyndsey | nutrition + fertility + herbalism + birth (@rooted_in_ritual) on Instagram: " Ways to Prepare for Ovulation Ovulation is the . Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. Mastron JK, Siveen KS, Sethi G, Bishayee A.Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Fried, M.; Navarro, V.; Afdhal, N. et al. The information and products shown on this website should not be interpreted as a substitute for physician evaluation or treatment. However, human studies are limited and havent yet shown any beneficial effects. Milk thistle is sold as an oral capsule, tablet and liquid extract. Due to its antioxidant and anti-inflammatory effects, milk thistle may be a useful supplement for people with acne. Get the facts on milk thistle for the liver. Zargani M, Ramirez-Campillo R, Arabzadeh E. Pflugers Arch. However, there is no solid evidence that supports these claims. Comparing Natural Remedies for OCD to Standard OCD Treatment Efficacy and safety of milk thistle preventive treatment of anti - LWW Exercise caution and start slow. What Is Complementary, Alternative, or Integrative Health? 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Milk Thistle (and liver cleansing) has two workings: it supports the liver and it lowers the inactive rT3 in favour of the active T3. 5th ed. It may also make chemotherapy work more effectively against certain cancers and, in some circumstances, even destroy cancer cells (9, 29, 30, 31). Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Milk thistle products appear to help the skin heal from damage caused by UVB radiation from the sun and may offer benefits in preventing non-melanoma skin cancers. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Herbal Remedies for OCD and Anxiety Disorders - Verywell Mind However, evidence suggests that milk thistle extracts might be useful in the treatment of mood disorders. JAMA. . Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Using different formulations together increases the risk of an overdose. Moreover, its unclear whether milk thistle is well enough absorbed in people to allow adequate amounts to pass through the blood-brain barrier. Abstract Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Phytother Res. Phytomedicine. This makes it very hard to establish a standard dose. See additional information. Adv Ther. Milk Thistle Benefits: 15 Ways This Super Herb Can Improve - Organixx Some, but not all, milk thistle supplements are vegan. However, as this is the only study, more high-quality research is needed. Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. Zhang Z, Wu H, Qi S, Tang Y, Qin C, Liu R, Zhang J, Cao Y, Gao X. Int J Environ Res Public Health. Well go over some of its most well-known benefits, Many people are interested in herbal supplements to support their liver health. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Silymarin (Silybum marianum; SM), popularly known as milk thistle, is an extract that has been used for many centuries to treat liver diseases. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Milk thistle supplements, for . A 2010 review by researchers found that black . There are other supplements that work similarly to milk thistle. Milk thistle often is used as a galactalogue, a food or supplement that people who are chest feeding take to improve milk production. 1. https://iocdf.org/about-ocd/ocd-treatment/meds/, International OCD Foundation, Medications for OCD, By By Michael Jenike, MD, Retrieved May 5, 2019, 2. https://theoakstreatment.com/blog/ocd-facts-and-statistics/, The Oaks Treatment, OCD Facts and Statistics, Published June 18, 2018, Retrieved May 5, 2019, 3. https://www.psycom.net/ocd-medication-guide/, Psycom.net, OCD Medication Guide, By Kathleen Smith, PhD, Last Updated September 21, 2018, 4. https://www.ncbi.nlm.nih.gov/pubmed/20564545, Phtotherapy Research, Milk thistle in liver diseases: past, present, future, Published October 24, 2010, Retrieved May 5, 2019, 5. https://www.drugs.com/npp/milk-thistle.html, Drugs.com, Milk Thistle, Last updated on Mar 1, 2019, Retrieved May 5, 2019, 6. https://www.verywellhealth.com/the-benefits-of-milk-thistle-88325, VeryWellHealth.com, The Benefits of Milk Thistle, By Kathee Wong, Updated March 08, 2019, Retrieved May 5, 2019, 7. https://linkinghub.elsevier.com/retrieve/pii/S0944711315000227, Phytomedicine, Effects of Silybum marianum (L.) Gaertn. Other SSRIs on the market include Fluvoxamine (Luvox), Paroxatine (Paxil), and Sertraline (Zoloft) (3). Milk thistle may interact with certain medications and supplements.